Core Technology

ENERGI-F701 (Alopecia Treatment, Topical Tonic)

ENERGI-F701 is meant to cure hair loss of men and women. We've proven that via enhancing the activity of AMPK, ENERGI-F701 can boost the ATP of human follicle dermal papilla cells (HFDPCs, Figure 1) thereby slowing down the aging speed and prolonging hair cycle (Figure 2). Meanwhile, animal test using Dihydrotestosterone (DHT) in simulating baldness shows that ENERGI-F701 is capable of alleviating the effect of DHT inhibiting hair growth (Figure 3), which underscores its potential for curing balding of men and women.

With the approval of U.S. FDA and Taiwan FDA, ENERGI-F701 will launch a phase II trial (NCT03351322) for female pattern hair loss (FPHL) at several medical centers in Taiwan in 2018 Q2.

Figure 1. ENERGI-F701 increases intracellular ATP in young (P5) and senescent (P16) human follicle dermal papilla cells (HFDPCs).

Figure 2. ENERGI-F701 prevents the senescence of HFDPCs. (a) Cell replications in control or ENERGI-F701 treated cells. (b) Comparison of cell senescence using b-galactosidase stains. (c) quantitation of figure 2b.

Figure 3. ENERGI-F701 restores dihydrotestosterone (DHT) induced alopecia in mice.